SANTA CLARA, Calif. — After a successful 10-day trip to New Jersey and West Virginia, the San Francisco 49ers returned home Sunday night and looked like a team that left its juice on the East Coast.

The Niners struggled from the start in a disappointing 25-20 loss to the Philadelphia Eagles. The defeat dropped the Niners to 2-2 on the season and 0-2 at Levi’s Stadium.

Perhaps of more concern is that this is the latest and, perhaps, costliest in a series of sluggish performances for the Niners after they have had an extended stay back East.

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Last season, the 49ers returned from a trip that included wins in Tampa Bay and in Cincinnati with